![]() ![]() Evidence from quantitative genetic studies and from genome-wide association (GWA) analyses suggest that pleiotropy (i.e., variants with simultaneous effects on several traits) is an important driver of the genetic correlation between comorbid conditions. Many human diseases (e.g., hypertension, gout, and diabetes) cluster into syndromes. Our results confirm previously reported loci and lead to several novel discoveries that link MetS-related traits through plausible biological pathways. We validate our results using previous studies documented in the GWAS-catalog and using data from GTEx. We found abundant pleiotropy and report 170, 44, and 18 genomic regions harboring SNPs with pleiotropic effects in at least two, three, and four of the seven traits, respectively. To demonstrate the use of the methods and software, we present a whole-genome scan in search of loci with pleiotropic effects on seven traits related to metabolic syndrome (MetS) using UK-Biobank data (n~300 K distantly related white European participants). #Sequential testing at intel softwareUsing simulations, we show that the methods implemented in the software are powerful and have adequate type-I error rate control. In this study, we present a sequential test and software that can be used to test pleiotropy in large systems of traits with biobank-sized data. This has limited the adoption of sequential testing for pleiotropy mapping at large scale. However, the existing methods and the available software do not scale to analyses involving millions of SNPs and large datasets. Sequential testing is a powerful approach for mapping genes with pleiotropic effects. Identifying variants with pleiotropic effects on multiple health-related traits can improve the biological understanding of gene action and disease etiology, and can help to advance disease-risk prediction. Please refer to the Launch Date for market availability.Pleiotropy (i.e., genes with effects on multiple traits) leads to genetic correlations between traits and contributes to the development of many syndromes. Functionality, performance, and other benefits of this feature may vary depending on system configuration. Please check with the system vendor to determine if your system delivers this feature, or reference the system specifications (motherboard, processor, chipset, power supply, HDD, graphics controller, memory, BIOS, drivers, virtual machine monitor-VMM, platform software, and/or operating system) for feature compatibility. ![]() ‡ This feature may not be available on all computing systems. Refer to Datasheet for formal definitions of product properties and features. Your company as an importer and/or exporter is responsible for determining the correct classification of your transaction. ![]() Any use made of Intel classifications are without recourse to Intel and shall not be construed as a representation or warranty regarding the proper ECCN or HTS. Intel classifications are for informational purposes only and consist of Export Control Classification Numbers (ECCN) and Harmonized Tariff Schedule (HTS) numbers. Please contact system vendor for more information on specific products or systems. The information herein is provided "as-is" and Intel does not make any representations or warranties whatsoever regarding accuracy of the information, nor on the product features, availability, functionality, or compatibility of the products listed. Intel may make changes to manufacturing life cycle, specifications, and product descriptions at any time, without notice.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |